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Product Overview
DDAVP Nasal Spray (Generic) is commonly prescribed to prevent or manage frequent urination and excessive water loss in people diagnosed with diabetes insipidus. Unlike diabetes mellitus (high blood sugar), diabetes insipidus is a rare condition where the kidneys cannot conserve water properly, leading to frequent urination and constant thirst. This can disrupt sleep and even cause bedwetting (enuresis), especially in children.
The active ingredient in DDAVP is desmopressin acetate, a synthetic hormone that mimics vasopressin, the body’s natural antidiuretic hormone. Vasopressin helps control water balance by signaling the kidneys to reabsorb water, reducing urine production.
How to Use
The typical adult dose is 1 to 4 sprays per day (0.1 to 0.4 ml), depending on the medical condition and how well you respond to treatment. For children aged 3 months to 12 years, the usual dosage is between 0.05 and 0.3 ml daily, either as a single dose or split into two smaller doses.
Do not use the spray more often than prescribed. It’s important to avoid drinking too much liquid while on DDAVP, as excessive fluid intake can lead to water retention and low sodium levels, which may be dangerous.
To use the spray correctly, avoid swallowing the medication or letting it drip into your mouth.
Possible Side Effects
Common side effects, especially with higher doses, may include:
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Nausea
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Headache
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Mild abdominal cramps
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Nasal irritation or congestion
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Facial flushing (redness of the skin)
Other less common reactions may include:
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Conjunctivitis (eye inflammation)
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Mood changes like depression or agitation
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Dizziness or drowsiness
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Rash or itching
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Swelling around the eyes or other areas of the body
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Chest pain or palpitations (strong, fast heartbeat)
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Indigestion and stomach discomfort
In rare cases, people may experience water intoxication, a serious condition caused by holding onto too much water, leading to swelling and low blood sodium levels.
Drug Interactions
Let your doctor know if you’re taking any of the following, as they can interact with DDAVP:
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Blood pressure medications like dopamine, epinephrine, efedrine, or norepinephrine (Levofed)
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Carbamazepine (for seizures)
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Chlorpropamide (for diabetes)
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Diuretics (water pills)
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Demeclocycline (an antibiotic)
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Glyburide or Clofibrate (for diabetes)
Important: Drinking alcohol while using DDAVP can reduce its effectiveness and may increase urination.
Missed Dose
If you forget a dose, take it as soon as you remember—unless it’s almost time for your next dose. Never double up to make up for a missed dose. Resume your usual schedule the next day at the regular time.
Overdose Warning
Taking too much DDAVP can be dangerous. Signs of overdose may include:
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Severe stomach cramps
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Headache
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Nausea
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Facial flushing
If you suspect an overdose, seek medical help right away.
Other Related Products
You might also explore Micronase and Glucotrol XL, which are popular in the same treatment category.
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